Action on alcohol--at last.

ACT‐ONE ‐ ACTION at last on cancer cachexia by adapting a novel action beta‐blocker

Novel action beta-blockers combine many different pharmacological effects. The espindolol exhibits effects through β and central 5-HT1α receptors to demonstrate pro-anabolic, anti-catabolic, and appetite-stimulating actions. In the ACT-ONE trial, espindolol reversed weight loss and improved handgrip strength in patients with cachexia due to non-small cell lung cancer or colorectal cancer. With ...

At most at last

Recent pragmatic accounts derive the ignorance inferences to which superlative modifiers give rise as quantity implicatures in a neo-Gricean framework. While these approaches successfully account for the interaction of at least with modals, the behavior of at most remains a puzzle. I propose that at most is composed of an antonymizing operator and at least and show how this accounts for the int...

Volcanic Shields on Mercury Identified at Last?

Introduction: Small (<50 km) basaltic shield volcanoes are known on Earth [1], the Moon [2], Mars [3] and Venus [4], but have not hitherto been positively identified on Mercury. A candidate on Mercury suggested by Head et al. on the basis of MESSENGER flyby imagery [5] was subsequently shown not to be a constructional edifice but to be a compound volcanic vent that had acted as a source only fo...

Action of Acid Alcohol on Insulin

Since the first isolation of insulin in a crystalline form (l), it has been a matter of the greatest interest to know whether this crystalline protein really represents insulin in its purest and most active form. The uniformity of the crystals, prepared in different laboratories, would, in appearance, chemical analysis, and physiological assay, point towards crystalline insulin being a chemical...

Community and municipal action on alcohol.